Photo Collage - Dec 2017

Photo Collage of Vosper Cousins

Hi everyone!  Thanks for sending in your headshots – the photo collage is attached.

 

Special thanks for the holiday greetings – you all are special to me, and I take delight in keeping in touch.

 

Hope you all have a Merry Christmas, Happy Hanukah, and a Happy New Year!

 

Cousin Teri

Living DNA

Hi Cousins!  Thought I’d let you know about a new DNA company in town.  They are different than the other DNA companies at the present time, because they are doing a GEOGRAPHIC matching within the British Isles.  They have recently begun advertising quite a bit – their company is called LIVING DNA.  Below is a copy of a portion of a friend of mines results, who comes from very recent English/Irish immigrants to America:

 

 

 

At the current time they are not doing “cousin matching” but I believe they plan to offer that feature in the coming year. 

 

I was a bit curious about how this would come out for me, so I am going to do a test with them.  Inasmuch as my most recent immigrant ancestor is Charles Vosper from Plymouth (b. 1865), with ancestors from Cornwall, I expect my strongest % will be Cornwall.  However, I have other ancestors who immigrated in the 1600s from Ireland, Scotland, and various places in England, and I’m interested in seeing the results.  You can be sure I will let you know how it turns out!

 

If you haven’t yet tested your DNA, I urge you to take advantage of the holiday sales and test with Ancestry.com. 

 

Just thought I’d send this out while I’m waiting for more Cousin headshots….

 

Later,

 

Cousin Teri

DNA comparisons for Cousin Robyn

Hi Robyn and Vosper Cousins,

 

Over the past few months I've been rather distracted, and several things have 'gotten by' me.  One of those things was comparing Robyn's DNA results with other Vosper cousins.  Today I have finally gotten to it!

 

First, a disclaimer – I track in detail the DNA of 5 Vosper Cousins – myself, my 2 brothers, my 1^st cousin Paula, and my 2^nd cousin, Robert Vosper.   If one of our Vosper Cousins does not match one of those 5 people I have no way to track their kit number, and they inadvertently may not be included in the results I show.  I apologize if this has happened to you – I just have no way to track that many kit #s.  If you have given me a kit # that does not show in the results below, and you'd like me to run the comparison, please re-send me your kit #....

 

OK!  Now for Robyn's results…..First a summary of the positive matches:

 

 

As you can see by the results above, sorted by chromosome number and start position, Robyn matches a number of our cousins, though mostly in small segments.  The exception is Bridget's DNA, where she has a large match.  Among the interesting things I noticed is that Robyn MOSTLY matches people from the New York branch of the Vospers that I descend from.  On the chart you'll notice that Bridget, Paula and Robyn all match on the 15^th chromosome between 89.3 and 91.9 – a very nice 9 cM match!

 

Here are the details, direct from GEDMatch, person by person, with the positive matches first:

 

I get the "teeniest tiniest segment match award" for my match with Robyn:

 

Cousin Paula gets the "matches the most" award, with a total of 13 cM:

 

Cousin Bridget gets the "largest single segment" award, with 11.6 cM:

Cousin Berniece has 2 matching segments:

 

Cousin Barbara (on Lesley Dawson's line) also has a match:

 

Cousin Monica matches on 2 segments:

 

Cousin Robert has 1 matching segment:

 

Cousin Yvonne, also in Australia, has 3 segments:

 

The chart below summarizes the lines that match DNA graphically:

 

 

The remainder of the cousins I tested did not have any matching segments:

 

 

 

 

 

 

 

 

 

 

 

I hope this helps you, Robyn in seeing how your DNA proves our lineage chart.  I would suggest that you add a name to your kit# -- I would suggest something like "Queensland Wms" or "Aus Wms" ….. something vague but suggestive….

 

If there are other Vosper Cousins out there who have DNA tested but have not downloaded to GedMatch, I hope you'll do so, so I can continue to document which segments come from which Vosper lineages.  Please contact me if you need help, and I'll be happy to do what I can.

 

Lastly, if you have sent me something that I have not worked on, I apologize, and beg you to please send me a reminder.  SO MANY things have scrolled off my email screens that it would take me forever to find them. 

I have become a co-director of my local DNA Interest Group, which meets monthly, and I'm afraid that my attention has become too split….

 

Hoping you are all ready for the Christmas season, and that you'll give a little shout-out to our Jewish Vosper origins in some form this year…. I like to think that our mixed religious heritage makes us all feel 'inclusive' during this special time of year….I know I feel that way.

 

 

Cousin Teri

DNA comparisons

Hi Andrea!  I’ve finished the DNA analysis (THANKS again, for downloading to Gedmatch!). 

 

The next step is to compare that with our known family relationship – which we don’t have!  I have attached the Vosper relationships we know in the Cousins Chart.    I have summarized what I understand of your Vosper lineage from your tree below:

 

George Vosper

          |

William R. Vosper m. Grace Manning

          |

Richard Vosper m. Elizabeth Hawkey

          |

Jane Vosper m. John Hurdle  

          |

Mary Ann Hurdle

          |

Rebecca Bussell

          |

Ernest Rice   (Canada)

          |

Gilbert George Rice

          |

Ernest Gilbert Rice

          |

    [Private]

          |

Andrea Rice (Sinclair)

 

That’s at least 8 generations from the closest Vosper. 

 

I don’t see a way to attach your tree to the Cousin Chart.  It’s possible that your tree and mine merge with George Vosper, but I don’t have enough facts to verify that.  A George Vosper from my tree:

https://www.ancestry.com/family-tree/person/tree/47009625/person/24453953948/facts

Could this be the same George Vosper from your tree?  https://www.ancestry.com/family-tree/person/tree/39844266/person/160137296233/facts

 

If so, the common ancestor would be Joseph Vosper who married Lyddia Isbell. 

 

Now, to the DNA:  With each generation, the amount of DNA you’d expect to have in common is reduced by 50%.  That’s 8 generations back for my family, 11 generations back for you.  So, in a best case scenario, we might expect to find .05% to .1% in common.  We have 3,589 cM, so .1% would be about 3.6 cM.  The “best case” would be if there was a “sticky segment” which stuck down through all the generations and was inherited.  Unfortunately, with the process of recombination, accidental matches can occur, which are generally considered to be in the 0-6cM range.  In other words, with small segment matches, like we would expect this many generations back, we can’t say for certain they are inherited (IBD) or accidental (IBS).

 

I’ve run your DNA against the individual tests for our Vosper Cousins, and have summarized on the Cousin Chart below, which shows highlighted those people you’ve had small segment matches with:

 

 

When you look at the individual DNA comparisons below you’ll see that the results include a start location, end location, and a cM length.  Most of the segments do not overlap – with one exception:

 

       Kit         Chr.     Start location      End location     cM

       Carol      9         106,367,615       109,734,883     5.0

       Aus         8             9,131,698         11,389,950     2.2

      Badarby 6         158,877,092       161,491,141     3.8

       Robert    8           13,744,265         16,443,534     2.7

       Jasf         8             9,158,808          11,538,674    2.3

       

The two small segments that Aus and Jasf match you on also overlap each other on Chr. 8, indicating  they MAY be an inherited segment, and thus a positive indicator of common inheritance.  In my (amateur) opinion, it is more likely that it is an inherited commonality than a random commonality.

 

Here are all the individual test results, which were obtained by using the gedmatch one to one comparison tool:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

I want to stress that, while a positive match is a sign of a definite relationship, a negative match is NOT a sign that there is no relationship.  A negative result is a natural occurrence of DNA recombination.

 

The bottom line is that we need to figure out how your family fits into our cousin chart – that is the best indicator of relationship that many generations back.  We need to work on getting George Vosper into the proper slot!

 

I have copied our Vosper Cousins on this email, and have also put a copy of the Vosper Blog.  

 

I’m so glad you’ve found our little group!

 

Cousin Teri

 

 

Longetivity in the Vosper Family

 

 

From: Sheila Stevens
Sent: Thursday, October 12, 2017 12:30 AM
Subject: Re: Some more Promethease results from Vosper Cousins

 

Good morning from Exeter UK, although my Mum and her Sister who have both passed away did not have DNA taken their Mum was our link to the Vosper's, my Aunty lived to 100 and my mum past away 4 years ago just before her 97th birthday. We did look at the Cornish ancestors finding longevity in that branch of our tree only. 

Therefore your findings are very interesting.

Thank you for copying me in your emails.

Sheila

Sheila Stevens 

FW: Some more Promethease results from Vosper Cousins

I got this message from "A revitalised cousin Lesley!"

Sister Monica and I have done the Promethease test and we both came up with 3 long lived genes, but one of them was this:

We are attributing the Vospers with this - do you have this variance?

Regards

Cousin Lesley

FW: [New post] Promethease 2017

Those of our cousins who have DNA tested MAY be interested in Promethease.  However, it is not for everyone.  Roberta (in the blog post below) does a good job of explaining what it is  and what it does and the up and down sides of running the report.

 

I have done it myself, and the results are a good reminder that I should NOT be eating processed meats.  The results are not something that I obsess about, but seeing the results of the genetic findings in black and white is a good reminder of WHY I should lead a healthy lifestyle.  

 

If you can look at your results and not obsess, I'd say 'go for it!' – it's well worth the money.

 

Cousin Teri

 

From: DNAeXplained - Genetic Genealogy [mailto:comment-reply@wordpress.com]
Sent: Sunday, October 8, 2017 10:46 AM

Subject: [New post] Promethease 2017

 

New post on DNAeXplained - Genetic Genealogy   Promethease 2017 by Roberta Estes For those who aren't acquainted with Promethease, they are a service that provides a comprehensive "health" report based on autosomal DNA results uploaded from the major testing companies.  You receive an informational report about your genetic health risks and some traits as reported in numerous academic studies that are archived and categorized relative to genetic information. Quoting Promethease, they say: Promethease is a literature retrieval system that builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia. Please note that if you took the 23andMe test for health information, Promethease provides you with exponentially more information – and you can utilize your 23andMe file to obtain that information. If you tested at any of the other major vendors, you can utilize those reports as well, either separately or together. I originally wrote about Promethease in December of 2013. At that time, I uploaded the files from various testing vendors to Promethease one by one and compared the results. Four years in this industry is forever, so I'm doing this again to share my results. There is a lot more information available from Promethease, and the testing vendors files have changed too. This time, I'm uploading my Exome data, a very different DNA test than consumers receive at the typical genetic genealogy testing companies. You can read about this test in the article, Genos – A Medically Focused DNA Exome Test. Keep in mind that even if you uploaded your autosomal file before and received results, Promethease adds new references as they become available, so your information from a couple years ago is out of date. The good news is that Promethease is very inexpensive, typically between $5 and $10. What Does Promethease Do? Promethease reports raw information, meaning that they do not massage or interpret this information for you. In other words, for a particular disease or trait, if there are 10 articles that report on that particular DNA location, based on your SNPs (one from Mom and one from Dad,) 2 information sources might indicate a possible increased risk, 5 might be neither good nor bad, and 3 might indicate a possible lower risk. Promethease shows you all 10, not distilling the 10 into a compilation or summary of your risk factors. Promethease is NOT DIAGNOSTIC. Only a physician can diagnose complex illnesses correctly, incorporating genetic information. I should note here that very few mutations are absolute, with a few notable exceptions like Huntington's Chorea. In most cases, just because you have a specific mutation indicating an elevated risk, does NOT means you'll ever get that disease. Other factors such as lifestyle, nutrition and environment are involved, as well as elements we don't yet understand today. Important If you decide to submit your information to Promethease, it's very important for you to understand and take the following points into consideration: ·         The DNA tests you are uploading are not medical tests. They do not test all possible locations. Furthermore, occasionally, tests run by different vendors produce different results at specific locations. Those differing results can and do produce conflicting information about traits or mutations associated with that location. ·         Testing errors occur. ·         Promethease results are not diagnostic, only informational. ·         If you are concerned about your health, either before or after testing, you should take the results and your concerns to your physician for interpretation in your particular situation. (I am not a doctor. This is common sense.) ·         The field of genetics, including medical genetics, is undergoing a steep learning curve. Very little is cast in concrete. Sometimes we learn that what we thought we knew previously was incorrect. ·         You cannot "unsee" what you will learn about your own genes and mutations. Be sure you really want to know before you participate in this type of learning. Having said all of that, let me share some interesting information about my results with you. My Results I recently uploaded my Genos Exome test, which tests a LOT more locations than any of the typical genetic genealogy tests – 50 million as compared to less than 1 million in the typical genealogy autosomal tests. I utilized Genos results on purpose, after developing a DVT (deep vein thrombosis – a blood clot) in my leg after a fall and after a flight, both. I wanted to see if I carry any genetic propensity for developing DVTs, or if it had just been a combination of circumstantial factors other than genetics. I discovered that I don't carry any known genetic predisposition to DVTs or other clotting issues. Neither did my parents, at least not that I know of. Promethease returned a total of 45,595 locations with informational results of some type, meaning those locations had been found in medical or academic literature housed at SNPedia. Of those locations, 41,766 were "good," 104 were "bad," and 3,725 were "not set" meaning neither good nor bad. The great news is that you don't need to read all of the results, but can search or see any results that are relevant for any particular word. So you can sort for "clot," "thrombosis" or even something like "kidney" or "liver," in addition to seeing and sorting information in various other ways. Most everyone looks at their "bad" mutations first. Fortunately, most people don't have many and often bad doesn't really mean "bad," simply a slight elevated risk. The Process When considering whether or not to utilize Promethease, you might want to take a look at the video provided on their main web page. Of course, to proceed, you'll need to actually READ the legal verbiage and click that you accept to proceed. Please click on any image to enlarge. Promethease said this, and I said this, but I want to say it again. You may discover things that will worry you. You may find conflicting information about a trait or mutation. You cannot "unsee" this once you've seen it. Vendor Upload Files You can upload your results from any of the vendors, noted above, as well as see example reports. Occasionally when a vendor changes something in their file, or changes testing chips, there will be a delay while Promethease makes adaptations. As I write this today, Promethease is working to handle the 23andMe V5 chip which is the new Illumina GSA chip. One VERY interesting feature is that you can upload your results from multiple vendors and Promethease will combine them to provide you with one report. This costs a little more - mine was $17.  If I didn't taken the Exome test, I would have uploaded all of my other files for combination. Actually, after I uploaded my Exome file and ran the results, I did upload the rest. I'll be publishing an article shortly with the results of that comparison titled "Imputation Analysis Utilizing Promethease." I would NOT utilize files from vendors that impute DNA data and include imputed information in your download data file. Of the vendors listed, I know that today MyHeritage makes use of imputed data on their site, but only downloads your actual tested locations, so their file would be fine to use. DNA.Land facilitates uploads from other vendors, then imputes additional results, allowing you to download the imputed data file. I would not suggest using this file. At this link, Promethease discusses imputation and says that some results from imputed information will be unreliable. I would recommend AGAINST using the imputed data. You will have no idea which results are from your real test and from the imputed data, that isn't actually yours. If you choose to use an imputed file, I would suggest that you also separately run the same file that you uploaded to DNA.Land in order to see which of your report locations are real and which are imputed by comparing the results of the two separate runs. Promethease provides information, shown below, about the various vendors and vendor files. Note that some are not accepted, and some are less reliable. It's interesting that the Family Tree DNA Big Y test is accepted in addition to their Family Finder autosomal test. The Results Processing takes about 20 minutes and you will receive an e-mail when processing is complete with a link to both view and download your report. Click "download" which provides a zip file. Results are only held on the Promethease website for 45 days unless you make a selection to retain your results on the website to enable future processing. Promethease provides a nice tutorial, both via their video and onscreen as well. Click the link in the e-mail to see your results. Promethease results are color coded with red being a probable pathogenic result (meaning potentially concerning, or bad), green being a good or protective result and grey meaning not assigned as bad or good – just information. In total, I had the following categories of results utilizing my Genos file: ·         Probably Pathogenic, red – 104 ·         Not Set, grey – 3725 ·         Protective, green – 41,766 Please note that while red equals bad, that's a relative thing. For example, having a "bad" mutation that MAY elevate your risk to 1.2% from 1% isn't really terribly concerning. Most of my "bad" mutations fall into this category, and may have good offsetting mutations for the same condition. So, no jumping to conclusions allowed and no panicking, please. Here's my first result. It's grey. Whew, I'm a female! You can see that I have 45,595 results returned, 10 being shown on the screen and the rest of the 45,595 being held in reserve and visible by sorting any number of ways, including by key word in the search box shown top right above. Below, lots of other sort options. Here's an example of a "grey" result when I searched for "eye color." You can see that this genotype, or result, as described, influences eye color.  I carry the nucleotides G and G, noted beside the rs id, where an A is required for the propensity to blue or grey eyes. From this information, we know that my children received a G from me, because that's all I have to give them, but if they received an A from their father, their eyes could be blue or grey. Caution If you don't want to know, and I mean really know about your medically connected mutations, don't utilize Promethease. If you are prone to anxiety or worry, this might not be for you. If you are a hypochondriac, for Heaven's sake, don't use Promethease. If you do want to know, run Promethease occasionally, because new SNPs are being added to the data base regularly. Be cautious about introducing this entire report into your medical record, especially given that the state of health care and pre-existing condition coverage is uncertain in the future in the US. However, be vigilant and inform your physician of anything that might be relevant to your conditions or treatment, or especially any variants that might help them diagnose a condition or tailor medications. While I am providing an informational article about this product, I am not specifically recommending or suggesting that anyone utilize Promethease.  That is an individual decision that everyone needs to make personally after weighing all the factors listed above, plus any not mentioned. ______________________________________________________________________ Standard Disclosure This standard disclosure will now appear at the bottom of every article in compliance with the FTC Guidelines. Hot links are provided to Family Tree DNA, where appropriate. If you wish to purchase one of their products, and you click through one of the links in an article to Family Tree DNA, or on the sidebar of this blog, I receive a small contribution if you make a purchase. Clicking through the link does not affect the price you pay. This affiliate relationship helps to keep this publication, with more than 850 articles about all aspects of genetic genealogy, free for everyone. I do not accept sponsorship for this blog, nor do I write paid articles, nor do I accept contributions of any type from any vendor in order to review any product, etc. In fact, I pay a premium price to prevent ads from appearing on this blog. When reviewing products, in most cases, I pay the same price and order in the same way as any other consumer. If not, I state very clearly in the article any special consideration received. In other words, you are reading my opinions as a long-time consumer and consultant in the genetic genealogy field. I will never link to a product about which I have reservations or qualms, either about the product or about the company offering the product. I only recommend products that I use myself and bring value to the genetic genealogy community. If you wonder why there aren't more links, that's why and that's my commitment to you. Thank you for your readership, your ongoing support and for purchasing through the affiliate link if you are interested in making a purchase at Family Tree DNA. Roberta Estes | October 8, 2017 at 5:45 pm | Tags: General Information | Categories: Medical, Promethease | URL: http://wp.me/p2AwO4-4Hn Comment    See all comments   Unsubscribe to no longer receive posts from DNAeXplained - Genetic Genealogy. Change your email settings at Manage Subscriptions. Trouble clicking? Copy and paste this URL into your browser: http://dna-explained.com/2017/10/08/promethease-2017/     Thanks for flying with WordPress.com